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The Cold Hard Facts
Dark Side of Statins Known but Not Revealed

Did you know that CoQIO depletions that cause the statin drugs'
well-known complications of myopathy (including cardio-myopathy)
and liver toxicity — and that the drugs' manufacturers are well
aware of this ?

In 1990, two patents were issued covering the use of CoQIO in
combination with statin drugs to prevent, treat, or ameliorate the
complications brought on by the drugs. The first patent (US Patent #1,
929,437), issued to Jonathan A. Tobert and assigned to Merck & Co.,
clearly states that by lowering CoQIO, the statin drugs can cause
predictable elevations of liver enzymes with liver damage. It also states
that by giving CoQIO along with the drugs this complication can be
prevented, or treated if it already exists.
A month later, a second patent (#4,933,165) was issued to Nobel laureate
Michael S. Brown, MD, well known in scientific circles for his work in fat
and choles¬terol metabolism. This patent, which was also assigned to
Merck, states that statin drugs, by causing a reduction in CoQIO, can
produce complications of muscle pain, weakness, and myopathy. The
patent covers a combina¬tion product of CoQIO added to a statin to
prevent these complications, plus the use of CoQIO for the treatment of
these complications.

Incredibly and inexplicably, Merck never exercised these patents, never
made combination CoQIO-statin products, and even more ominous, never
attempted to educate physicians or patients about the very dangerous
statin-CoQIO connection. Even though patients are informed of potential
side effects of muscle weakness and soreness and liver enzyme elevation,
they are not told that this is likely due to the drug's reduction of CoQIO.
Nor are they told that by supplementing with CoQIO they could prevent or
eliminate these problems. And there have been consequences.

"Miracle Drugs" or Public Health Menace?

As you may recall, one statin drug, Baycol, was taken off the market
because it was linked to hundreds of cases of severe muscle myopathy
and rhabdomyolysis (complete muscle breakdown), including dozens of
fatalities. Had the patients taking Baycol been given CoQIO as well, we
believe they likely would have avoided these deadly complications.

hi spite of the fact that Baycol was removed from the market, there has
been no mention whatsoever by any of the drug companies or the press
that CoQIO deficiencies may have been the likely culprit. This is
particularly vexing since the patent that was issued over a decade ago
clearly outlines the mechanism that caused these problems. We who have
been yelling about the statin-CoQIO connection (and there are alarmingly
few of us) are beginning to feel like the Aflac duck — our warnings are
falling on deaf ears.

We now have a huge public health disaster in the making. It is predicted
that with the new cholesterol guidelines made last year by the National
Cholesterol Educational Program, the number of Americans taking statin
drugs will increase from the current 13 million to 36 million. The problems
that may arise as a result of the inevitable CoQIO depletions that will
occur in these millions of people are staggering. Hundreds of thousands
of people could be severely damaged by these drugs, virtually all of them
unnecessarily.

Urgent Need for a Global Response  

There should be a required warning on the labels of the statin cholesterol-
lowering drugs stating that they block the production of CoQIO and put
people at risk of side effects. These side effects (liver dysfunction and
myopathy, including cardiomyopathy and congestive heart failure) are
specifi¬cally caused by drug-induced reduction of CoQIO levels. The label
warning should clearly state that patients taking statin drugs should also
take 100 to 200 mg of CoQIO to prevent and treat these side effects.
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